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The bestselling introduction to bioinformatics and functional genomics – now in an updated edition
Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.
This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:
- Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions
- A completely updated companion web site, which will be updated as new information becomes available – visit www.wiley.com/go/pevsnerbioinformatics
- Descriptions of genome sequencing projects spanning the tree of life
- A stronger focus on how bioinformatics tools are used to understand human disease
Bioinformatics and Functional Genomics is complemented by lavish illustrations and more than 500 figures and tables – fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.
Preface to the Second Edition
Preface to the First Edition
Foreword
PART I ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES
1 Introduction
2 Access to Sequence Data and Literature Information
3 Pairwise Sequence Alignment
4 Basic Local Alignment Search Tool (BLAST)
5 Advanced Database Searching
6 Multiple Sequence Alignment
7 Molecular Phylogeny and Evolution
PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN
8 Bioinformatic Approaches to Ribonucleic Acid (RNA)
9 Gene Expression: Microarray Data Analysis
10 Protein Analysis and Proteomics
11 Protein Structure
12 Functional Genomics
PART III GENOME ANALYSIS
13 Completed Genomes
14 Completed Genomes: Viruses
15 Completed Genomes: Bacteria and Archaea
16 The Eukaryotic Chromosome
17 Eukaryotic Genomes: Fungi
18 Eukaryotic Genomes: From Parasites to Primates
19 Human Genome
20 Human Disease
Glossary
Answers to Self-Test Quizzes
Author Index
Subject Index
"[...] provides non-trivial tools and biological motivations to learn bioinformatics."
- Journal of Statistical Computation & Simulation, January 2005
" [...] ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms."
- Quarterly Review of Biology, March-May 2005
" [...] this appears to be an excellent textbook for graduate students and upper level undergraduate students."
- Annals of Biomedical Engineering, July 2004 32,7
" [...] highly recommended for academic and medical libraries, and for researchers as an introduction and reference [...] "
- E-Streams, Vol. 7, No. 4
" [...] an intriguing work targeted toward biologists wanting to solve problems [...] provides a compendium of many biological insights and breakthroughs and will be a useful resource [...] highly recommended."
- Choice, Vol. 41, No. 7, March 2004
