Basic Virology

About this book

Basic Virology, 4th edition cements this book's position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

This undergraduate-accessible book covers all the foundational topics in virology, including:
- The basics of virology
- Virological techniques
- Molecular biology
- Pathogenesis of human viral disease

The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. Basic Virology also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.

Contents

Preface
Preface to the Second Edition
Preface to the Third Edition
Preface to the Fourth Edition
Acknowledgements

Part I. Virology and viral disease
Chapter 1. Introduction – the impact of viruses on our view of life
Chapter 2. An outline of virus replication and viral pathogenesis
Chapter 3. Virus disease in populations and individual animals
Chapter 4. Patterns of some viral diseases of humans

Part II. Basic properties of viruses and virus-cell interaction
Chapter 5. Virus structure and classification
Chapter 6. The beginning and end of the virus replication cycle
Chapter 7. The innate immune response: early defense against pathogens
Chapter 8. Strategies to protect against and combat viral infection

Part III. Working with virus
Chapter 9. Visualization and enumeration of virus particles
Chapter 10. Replicating and measuring biological activity of viruses
Chapter 11. Physical and chemical manipulation of the structural components of viruses
Chapter 12. Characterization of viral products expressed in the infected cell
Chapter 13. Viruses use cellular processes to express their genetic information

Part IV. Replication patterns of specific viruses
Chapter 14. Replication of positive-sense RNA viruses
Chapter 15. Replication strategies of RNA viruses requiring RNA-directed mRNA transcription as the first step in viral gene expression
Chapter r6. Replication strategies of small and medium-sized DNA viruses
Chapter 17. Replication of some nuclear-replicating eukaryotic DNA viiruses with large genomes
Chapter 18. Replication of cytoplasmic DNA viruses and “large” bacteriophages
Chapter 19. Retroviruses: converting RNA to DNA
Chapter 20. Human Immunodeficiency Virus type 1 (HIV-1) and related lentiviruses
Chapter 21. Hepadnaviruses: variations on the retrovirus theme

Part V. Molecular genetics of viruses
Chapter 22. The molecular genetics of viruses
Chapter 23. Molecular pathogenesis
Chapter 24. Viral bioinformatics
Chapter 25. Viruses and the future – problems and promises

Appendix
Resource Center
Technical Glossary
Index

Customer Reviews

Biography

Martinez J. Hewlett is Professor Emeritus in the Department of Molecular and Cellular Biology at the University of Arizona. David Camerini is an Assistant Professor in the Department of Molecular Biology and Biochemistry at the University of California Irvine. David C. Bloom is Associate Professor in the Department of Molecular Genetics and Microbiology at the University of Florida.