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Derived from the best-selling classic text originated by Lubert Stryer and continued by John Tymoczko and Jeremy Berg, Biochemistry: A Short Course focuses on the major topics taught in a one-semester biochemistry course. With its short chapters and relevant biological and clinical examples, this text shows biochemistry as a part of students' everyday lives. Offering the same signature writing style and physiological emphasis as the full-length text, this briefer book focuses on the major topics by eliminating details of enzyme mechanisms and organic chemistry, and by removing extraneous and advanced topics. Coverage is broken into short chapters for ease of use.
Numerous examples and photos of biochemistry in action show students that biochemistry is part of everything they do and experience. Students learn a biochemical concept, then see how that concept is applied in the real world. Clinical Insights show how our understanding of biochemical concepts influences an aspect of a disease or its cure, and Biological Insights show how simple changes in biochemical processes can have dramatic effects. The Second Edition has been fully updated with coverage of recent developments in biochemistry and human health. New Metabolism in Context sections show how new information on the role of leptins in hunger and satiety has changed the way biochemists think about obesity and
addition to diet and obesity, other Metabolism in Context features focus on metabolism and cancer, and metabolism and exercise. The Experimental Techniques chapters (available on the companion website) have also been updated and expanded, exploring important techniques used by biochemists in the past as well as new technologies with which biochemists make discoveries in present-day laboratories. (This title may not be available in all areas. Please contact your representative for more information.)
PART I: THE MOLECULAR DESIGN OF LIFE
- Biochemistry Helps Us Understand Our World
- Biochemistry and the Unity of Life
- Water, Weak Bonds, and the Generation of Order Out of Chaos
- Protein Composition and Structure
- Amino Acids
- Protein Three-Dimensional Structure
- Basic Concepts and Kinetics of Enzymes
- Basic Concepts of Enzyme Action
- Kinetics and Regulation
- Mechanisms and Inhibitors
- Hemoglobin, an Allosteric Protein
- Carbohydrates and Lipids
- Carbohydrates
- Lipids
- Cell Membranes, Channels, Pumps, and Receptors
- Membrane Structure and Function
- Signal-Transduction Pathways
PART II: TRANSDUCING AND STORING ENERGY
- Basic Concepts and Design of Metabolism
- Digestion: Turning a Meal into Cellular Biochemicals
- Metabolism: Basic Concepts and Design
- Glycolysis and Gluconeogenesis
- Glycolysis
- Gluconeogenesis
- The Citric Acid Cycle
- Preparation for the Cycle
- Harvesting Electrons from the Cycle
- Oxidative Phosphorylation
- The Electron-Transport Chain
- The Proton-Motive Force
- The Light Reactions of Photosynthesis and the Calvin Cycle
- The Light Reactions
- The Calvin Cycle
- Glycogen Metabolism and the Pentose Phosphate Pathway
- Glycogen Degradation
- Glycogen Synthesis
- The Pentose Phosphate Pathway
- Fatty Acid and Lipid Metabolism
- Fatty Acid Degradation
- Fatty Acid Synthesis
- Lipid Synthesis: Storage Lipids, Phospholipids, and Cholesterol
- The Metabolism of Nitrogen-Containing Molecules
- Amino Acid Synthesis
- Nucleotide Metabolism
- Amino Acid Degradation and the Urea Cycle
PART III: SYNTHESIZING THE MOLECULES OF LIFE
- Nucleic Acid Structure and DNA Replication
- The Structure of Informational Macromolecules: DNA and RNA
- DNA Replication
- DNA Repair and Recombination
- RNA Synthesis, Processing, and Regulation
- RNA Synthesis and Regulation in Prokaryotes
- Gene Expression in Eukaryotes
- RNA Processing in Eukaryotes
- Protein Synthesis
- The Genetic Code
- The Mechanism of Protein Synthesis
PART IV: EXPERIMENTAL BIOCHEMISTRY (available online on the Companion Website)
- Techniques in Protein Biochemistry
- Immunological and Recombinant DNA Techniques
John L. Tymoczko is Towsley Professor of Biology at Carleton College, USA. Jeremy M. Berg was Professor and Director of the Department of Biophysics and Biophysical Chemistry at Johns Hopkins University School of Medicine, USA, where he remained until 2003. He then became Director of the National Institute of General Medical Sciences at the National Institutes of Health. Lubert Stryer Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, USA, where he has been on the faculty since 1976. The publication of his first edition of Biochemistry in 1975 transformed the teaching of Biochemistry.
