Fermentation Microbiology and Biotechnology

About this book

Fermentation Microbiology and Biotechnology, Second Edition provides a current overview of fermentation biotechnology, with special attention paid to key application areas and novel support technologies. This edition features updated and expanded chapters that present the most recent advances in the field. It discusses enzymes and metabolic engineering for the production of fine chemicals and pharmaceuticals. Additional coverage includes principles and applications of fermentation kinetics, bioprocess monitoring, metabolic flux analysis, and effective control systems and strategies. It is an ideal text for students and a handy reference for busy professionals in a variety of fields.

Contents

Fermentation Microbiology and Biotechnology: An Historical Perspective, M. El-Mansi, C.F.A. Bryce, B. S. Hartley, and A. L. Demain Fermentation: An ancient tradition The rise of fermentation microbiology Developments in metabolic and biochemical engineering Discovery of antibiotics and genetic engineering The rise and fall of single cell protein Fermentation biotechnology and the production of amino acids Impact of functional genomics, proteomics, metabolomics and bio-informatics on the scope and future prospects of fermentation microbiology and biotechnology Microbiology of Industrial Fermentation, M. El-Mansi and F.B. Ward Chemical synthesis of bacterial protoplasm/biomass The growth cycle Diauxic growth Growth yield in relation to carbon and energy contents of growth substrates Fermentation balances Efficiency of central metabolism Continuous cultivation of micro-organisms Current advances and innovations in the fermentation and pharmaceutical industry Microbial fermentations and the production of biopharmaceuticals Fermentation Kinetics, J. Nielsen Framework for kinetic models Mass balances for bioreactors Kinetic models Population models NEW! Microbial Synthesis of Primary Metabolites: Current Advances and Future Prospects, A. L. Demain and S. Sanchez Control of primary metabolism Approaches to strain improvements Production of primary metabolites Microbial Synthesis of Secondary Metabolites and Strain Improvement, I. S. Hunter The economics and scale of microbial product fermentations Different products need different fermentation processes Fed-batch culture; the paradigm for many efficient microbial processes Tactical issues for strain improvement programs Strain improvement: The random,

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