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Newly revised and updated, the Fourth Edition of Molecular Biology: Genes to Proteins is a comprehensive guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. Written for the undergraduate and first year graduate students within molecular biology or molecular genetics, the text has been updated with the latest data in the field. It incorporates a biochemical approach as well as a discovery approach that provides historical and experimental information within the context of the narrative. Reorganized to allow instructors to build on critical concepts throughout the course. Updated content on replication, transcription, and translation. A new chapter describing small silencing RNAs. New section added to examine RNA structure in greater detail. Includes a new section describing the ubiquitin proteasome proteolytic pathway. The section on DNA sequence has been updated to include the new generation of DNA sequencers. New sections have been added that examine epigenetic programming, which includes a discussion of imprinting and induced pluripotent stem (iPS) cells.
Section I Introduction
Chapter 1 1. Introduction to Molecular Biology
Section II Protein Structure and Function
Chapter 2 Protein Structure
Chapter 3 Protein Function
Section III Nucleic Acids and Nucleoproteins
Chapter 4 Nucleic Acid Structure
Chapter 5 Techniques in Molecular Biology
Chapter 6 Chromosome Structure
Section IV Genetics and Virology
Chapter 7 Genetic Analysis in Molecular Biology
Chapter 8 Viruses in Molecular Biology
Section V DNA Metabolism
Chapter 9 DNA Replication in Bacteria
Chapter 10 DNA Replication in Eukaryotes and the Archaea
Chapter 11 DNA Damage
Chapter 12 DNA Repair
Chapter 13 Recombination
Chapter 14 Transposons and Other Mobile Elements
Section VI RNA Metabolism
Chapter 16 Regulation of Bacterial Gene Transcription
Chapter 17 RNA Polymerase II: Basal Transcription
Chapter 18 RNA Polymerase II: Regulation
Chapter 19 RNA Polymerase II: Cotranscriptional and Posttranscriptional Processes
Chapter 20 RNA Polymerases I and III and Organellar RNA Polymerases
Section VII Protein Synthesis
Chapter 21 Small Silencing RNAs
Chapter 22 Protein Synthesis: The Genetic Code
Chapter 23 Protein Synthesis: The Ribosome
Burton Tropp received a Ph.D. in Biochemistry and Molecular Biology from Harvard University. After completing his graduate research on the mechanism of methylation of transfer RNA he studied protein synthesis in regenerating rat liver while a post-doctoral fellow in the Department of Microbiology and Immunology at the Harvard Medical School. He then joined the faculty of the City University of New York where he is currently a professor in the Department of Chemistry and Biochemistry at Queens College and in the Ph.D. Biochemistry Program at the City University of New York Graduate Center. He teaches biochemistry and biochemical genetics at both the undergraduate and graduate levels. His major research interest has been the genetic aspects of lipid metabolism. He has authored more than 50 peer-reviewed papers in this research area.
