Bioinorganic Chemistry Inorganic Elements in the Chemistry of Life - An Introduction and Guide

About this book

The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature.

Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances.

Topics covered include:
- Metals at the center of photosynthesis
- Uptake, transport, and storage of essential elements
- Catalysis through hemoproteins
- Biological functions of molybdenum, tungsten, vanadium and chromium
- Function and transport of alkaline and alkaline earth metal cations
- Biomineralization
- Biological functions of the non-metallic inorganic elements
- Bioinorganic chemistry of toxic metals
- Biochemical behavior of radionuclides and medical imaging using inorganic compounds
- Chemotherapy involving non-essential elements

This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.

Contents

Preface to the Second Edition xi
Preface to the First Edition xiii

1 Historical Background, Current Relevance and Perspectives 1
2 Some General Principles 7
3 Cobalamins, Including Vitamin and Coenzyme B12 37
4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57
5 The Dioxygen Molecule, O₂: Uptake, Transport and Storage of an Inorganic Natural Product 77
6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates  99
7 Iron–Sulfur and Other Non-heme Iron Proteins 117
8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139
9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal 163
10 Copper-containing Proteins: An Alternative to Biological Iron 183
11 Biological Functions of the “Early” Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium  211
12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of
13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth
14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions
15 Biomineralization: The Controlled Assembly of “Advanced Materials” in Biology 295
16 Biological Functions of the Nonmetallic Inorganic Elements 315
17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327
18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds 349
19 Chemotherapy Involving Nonessential Elements 369

Further Reading 389
References 389
Index

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