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28 plates with colour photos and colour illustrations
Clarifying much of the inconsistency currently encountered in the scientific literature, Histological Analysis of Endocrine Disruptive Effects on Small Laboratory Fish helps to standardize the interpretation of results from aquatic bioassays and field observations by describing basic biological function and contrasting normal histology with histopathological conditions in a variety of fish species. The authors represent the leaders of small fish gonadal histopathology, and they incorporate views and ideas from other experts.
Preface xi
Acknowledgments xiii
Contributing Authors xv
1 Introduction 1
2 Fish Species of Interest 7
3 Sexual Determination, Differentiation, and Gonadal Development 19
4 Female Gonad Anatomy and Morphology 66
5 Male Gonad Anatomy and Morphology 88
6 Endocrine-Disrupting Compounds 115
7 Determination of Effects of Exogenous Hormones and Endocrine-like Active Compounds 247
8 Evaluation of Effects in Fish Gonads 254
9 Experimental Design and Statistics 270
10 Conclusions 295
Appendix: Fish Preparation and Microdissection of Organs 301
A.1 Fish Preparation 301
A.2 Microdissection of Organs 302
A.3 Tissue Fixation 303
A.4 Embedding 307
A.5 Tissue Sectioning 310
A.6 Sample Mounting 311
A.7 Tissue Slide Staining 312
A.8 Final Processing 315
A.9 Examples 316
A.10 Summary 317
References 318
Index 319
Daniel R. Dietrich, PhD, is a Professor and Head of the Human and Environmental Toxicology Group, Faculty of Sciences of the University of Konstanz, Konstanz, Germany. Heiko O. Krieger, MSc, is a scientific research assistant and PhD student in the Human and Environmental Toxicology Group, Faculty of Sciences of the University of Konstanz, Konstanz, Germany.
