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Membrane Structural Biology brings together a physicochemical analysis of the membrane with the latest structural biology on membrane lipids and proteins to offer an exciting portrayal of biomembranes.
Written with remarkable clarity, this text appears at a time when membranes have moved back into the scientific spotlight and will provide a unique foundation for advanced students and working scientists. The structure, function and biogenesis of membrane lipids and proteins are examined, bioinformatics and computational approaches to membrane components are introduced, and the high-resolution structures that are giving new insights into the vital roles membranes play are discussed. The many correlations between membrane research and human health are discussed and key themes for future work in this area are identified. Membrane structural biology is poised to answer many basic and applied questions and this cutting-edge text will provide a solid grounding for all those working in this field.
1. Introduction
2. The diversity of membrane lipids
3. Tools for studying membrane components: detergents and model systems
4. Proteins in or at the bilayer
5. Bundles and barrels
6. Functions and families
7. Protein folding and biogenesis
8. Diffraction and simulation
9. Membrane enzymes and transducers
10. Transporters and channels
11. Membrane protein complexes as nanomachines
12. Key themes and future directions
Professor Mary Luckey is a Professor in the Department of Chemistry and Biochemistry at San Francisco State University. She earned her Ph.D. in biochemistry at U.C. Berkeley with the first identification of an iron transport protein in the bacterial outer membrane. Her postdoctoral work demonstrated the specificity of the E. coli maltoporin in proteoliposomes. While continuing research on maltoporin structure and function, she has taught biochemistry for twenty-five years, including the graduate-level membrane biochemistry course that provided the impetus for this book.
