The Cytoskeleton

About this book

The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins.

The Cytoskeleton presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The Cytoskeleton is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

Contents

Preface
Overview of the Cytoskeleton from an Evolutionary Perspective
    Thomas D. Pollard and Robert D. Goldman

PART 1. CYTOSKELETAL AND MOTILITY PROTEINS
Actin and Actin-Binding Proteins
    Thomas D. Pollard
Microtubules and Microtubule-Associated Proteins
    Holly V. Goodson and Erin M. Jonasson
Intermediate Filaments: Structure and Assembly
    Harald Herrmann and Ueli Aebi
Motor Proteins
    H. Lee Sweeney and Erika L.F. Holzbaur
Cytoskeleton Integrators: The Spectrin Superfamily
    Ronald K.H. Liem

PART 2. CYTOSKELETON IN CELL AND TISSUE ARCHITECTURE
Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells
    Alexia I. Bachir, Alan Rick Horwitz, W. James Nelson, and Julie M. Bianchini
The Centrosome, a Multitalented Renaissance Organelle
    Anastassiia Vertii, Heidi Hehnly, and Stephen Doxsey
Types I and II Keratin Intermediate Filaments
    Justin T. Jacob, Pierre A. Coulombe, Raymond Kwan, and M. Bishr Omary
Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin
    Elly M. Hol and Yassemi Capetanaki
Neurofilaments and Neurofilament Proteins in Health and Disease
    Aidong Yuan, Mala V. Rao, Veeranna, and Ralph A. Nixon
Intermediate Filaments and the Plasma Membrane
    Jonathan C.R. Jones, Chen Yuan Kam, Robert M. Harmon, Alexandra V. Woychek, Susan B. Hopkinson, and Kathleen J. Green
The Nucleoskeleton
    Stephen A. Adam
Mechanical Properties of the Cytoskeleton and Cells
    Adrian F. Pegoraro, Paul Janmey, and David A. Weitz

PART 3. INTRACELLULAR TRANSPORT
Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles
    Kari Barlan and Vladimir I. Gelfand
Intraflagellar Transport and Ciliary Dynamics
    Hiroaki Ishikawa and Wallace F. Marshall
Intracellular Motility of Intermediate Filaments
    Rudolf E. Leube, Marcin Moch, and Reinhard Windoffer
Myosin-Driven Intracellular Transport
    Margaret A. Titus

PART 4. CELLULAR MOTILITY
The Actin Cytoskeleton and Actin-Based Motility
    Tatyana Svitkina
Muscle Contraction
    H. Lee Sweeney and David W. Hammers
Ciliary Motility: Regulation of Axonemal Dynein Motors
    Rasagnya Viswanadha, Winfield S. Sale, and Mary E. Porter
Intermediate Filaments and the Regulation of Cell Motility during Regeneration and Wound Healing
    Fang Cheng and John E. Eriksson

PART 5. CELL DIVISION
Mitosis
    J. Richard Mcintosh
Cytokinesis in Metazoa and Fungi
    Michael Glotzer

Index

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