The present work is the result of an over 30 years extensive study of discomycetes, a former taxonomic class of Ascomycete fungi, recognized in the family Orbiliaceae, which was previously considered as a comparatively small group within the Helotiales but later raised to the level of a class. This study resulted in the recognition of worldwide ~470 species with a known teleomorph, 331 of which being validly described here as new to science. The authors also propose 38 new combinations and 2 nomina nova, and designate 33 epitypes, 39 lectotypes, 3 neotypes, and 4 reference specimens, including some misplaced species now referred to other classes.