About this book
The Machinery of Life is a journey into the sub-microscopic world of molecular machines. Readers are introduced to the types of molecules built by cells, including proteins, nucleic acids, lipids, and polysaccharides; then, in a series of full-color "watercolour" illustrations, which show a portion of a living cell magnified by 1,000,000 times, the reader is guided through the interior world of cells. The book explores the ways in which molecules work in concert to perform the processes of living, and how vitamins, viruses, poisons, and drugs each have their effects on the molecules in our bodies. The book is a fascinating introduction to biochemistry for the non-specialist, and combines a lucid text with an abundance of drawings and computer graphics that present the world of cells and their components in a truly unique way.
This new edition has been updated to include the many major advances of the past decade, and is richly illustrated in full colour throughout.
Contents
Preface
1 Introduction
A Matter of Scale
The Molecular World
2 Molecular Machines
Nucleic Acids
Proteins
Lipids
Polysaccharides
The Strange World of Molecules in Cells
3 The Processes of Living
Building Molecules
Harnessing Energy
Protection and Perception
4 Molecules in Cells: Escherichia coli
The Protective Barrier
Building New Proteins
Powering the Cell
Cellular Propellers
Molecular Warfare
5 A Human Cell: The Advantages of Compartments
6 The Human Body: The Advantages of Specialization
Infrastructure and Communication
Muscle
Blood
Nerves
7 Life and Death
Ubiquitin and the Proteasome
DNA Repair
Telomeres
Programmed Cell Death
Cancer
Aging
Death
8 Viruses 127
Poliovirus and Rhinovirus
Influenza Virus
Human Immunodeficiency Virus
Vaccines
9 You and Your Molecules
Vitamins
Broad-Spectrum Poisons
Bacterial Toxins
Antibiotic Drugs
Drugs and Poisons of the Nervous System
You and Your Molecules
Atomic Coordinates
Additional Reading
Index
Customer Reviews
Biography
Dr. David S. Goodsell is Associate Professor in the Department of Molecular Biology at The Scripps Research Institute, La Jolla, CA, USA. His illustrations have become well known and now appear in many publications as the primary demonstration of the crowded nature of cells. He has also provided expertise and illustrations to many science museums, most recently acting as a "thinking partner" for a new multi-site nanotechnology initiative headed in part by the Exploratorium in San Francisco.