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Tools and Techniques in the Biomolecular Sciences reviews the theoretical concepts and experimental details underpinning the broad range of modern technologies that are currently being used to advance our understanding of the biomolecular sciences. Each chapter focuses on the theoretical principles of a given technology, and its applications and limitations, before using worked examples to illustrate the nature of the data a particular technique generates.
Fostering active engagement with the techniques presented, each chapter uses worked examples and problems to encourage the reader to critically appraise scientific data and select the most appropriate methods when designing an experimental strategy to undertake their own research. Its straightforward style and clear explanations make Tools and Techniques in the Biomolecular Sciences the ideal resource for any student or early-stage researcher who is looking to develop a firm understanding of the range of experimental tools at their disposal.
1: Gene cloning strategies
2: PCR
3: DNA mutagenesis
4: DNA sequencing
5: Measuring DNA/protein interactions
6: RNA interference technology
7: Microarrays
8: Recombinant protein expression
9: Protein purification
10: Antibody technology
11: Measuring protein/protein interactions
12: Structural analysis of proteins I - Mass spectroscopy
13: Structural analysis of proteins II
14: Proteomic analysis
15: Bioinformatics: gene sequence analysis
16: Bioinformatics: protein sequence analysis
17: Histology
18: Culturing cells
19: Flow cytometry
20: Bioimaging
21: Model organisms
22: Mathematical models in biomolecular sciences
Dr Aysha Divan is a lecturer in the Faculty of Biological Sciences at the University of Leeds, where her laboratory-based research explores chromatin remodelling and tumour biology, and her pedagogical research examines postgraduate-level communication and technical skills training in the biosciences.
Dr Janice Royds is a lecturer in the Department of Pathology at the University of Otago, New Zealand. Her broad ranging biomedical research interests relate to cancer biology, while her extensive teaching experience at both undergraduate and postgraduate level include pathology, pharmacology, and the molecular biology of cancer.
Contributors:
Professor David Hornby- Department of Molecular Biology and Biotechnology, University of Sheffield
Dr Qaiser I Sheikh- Department of Molecular Biology and Biotechnology, University of Sheffield
Dr Martin Evison- Centre for Forensic Science, Northumbria University
Professor Mike McPherson- Faculty of Biological Sciences, University of Leeds
Dr Tania Slatter- Department of Pathology, University of Otago
Dr Alison Fitches- Department of Pathology, University of Otago
Dr Luis G Acevedo- Active Motif, Inc., California
Ana Sanz- Active Motif, Inc., California
Mary Anne Jelinek- Active Motif, Inc., California
Paul Labhart- Active Motif, Inc., California
Dr Ian Hampson- School of Medicine, The University of Manchester
Mr Gavin Batman- School of Medicine, The University of Manchester
Thomas Walker- School of Medicine, The University of Manchester
Dr Naveed Aziz- Director, Technology Programs, Genome Canada
Dr Mike Harrison- Faculty of Biological Sciences, University of Leeds
Dr Iain Manfield- Faculty of Biological Sciences, University of Leeds
Professor John Colyer- Faculty of Biological Sciences, University of Leeds
Dr Johanna Avis- Faculty of Life Sciences, University of Manchester
Dr Sanjay Nilapwar- Faculty of Life Sciences, University of Manchester
Professor Alison Ashcroft- Faculty of Biological Sciences, University of Leeds
Dr James Ault- Faculty of Biological Sciences, University of Leeds
Dr Thomas Edwards- Faculty of Biological Sciences, University of Leeds
Dr Arwen Pearson- Faculty of Biological Sciences, University of Leeds
Dr David Brockwell- Faculty of Biological Sciences, University of Leeds
Dr Ollie Farrance- Faculty of Biological Sciences, University of Leeds
Dr Gareth Morgan- The Scripps Research Institute, California
Dr Gary Thompson- Faculty of Biological Sciences, University of Leeds
Dr Arnout Kalverda- Faculty of Biological Sciences, University of Leeds
Dr Richard Unwin- Centre for Advanced Discovery and Experimental Therapeutics, Central Manchester University Hospitals, NHS Foundation Trust
David Lewis- School of Biosciences, University of Nottingham
Professor Charlie Hodgman- School of Biosciences, University of Nottingham
Dr Noelyn Hung- Department of Pathology, University of Otago
Professor Geoffrey J Pilkington- School of Pharmacy and Biomedical Sciences, University of Portsmouth
Dr Laura K. Donovan- School of Pharmacy and Biomedical Sciences, University of Portsmouth
Dr John Lawry- Beckton Dickinson, Cambridge
Dr Gareth Howell- Faculty of Biological Sciences, University of Leeds
Dr Kyle Dent- Faculty of Biological Sciences, University of Leeds
Dr Jeannie Chin- Department of Neuroscience and Farber Institute for Neurosciences, Thomas Jefferson University
Dr Jose Garcia- Department of Preventive and Social Medicine, Otago University
