Actin

Series: Protein Profile Series

By: Peter Sheterline, Jon Clayton and John C Sparrow

176 pages, 8 b/w photos, 38 line illus

Publisher: Oxford University Press

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ISBN: 9780126399851 Edition: 3 Hardback Dec 1996 Out of Print #64531

About this book Contents

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About this book

Actins are a highly conserved family of proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility - from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins families from myosins to gelsolins. This up-to-date edition gives a comprehensive account of actin sequence, mutation and structure as well as providing insight into ligand-binding sites and drug and toxin binding. Illustrated throughout, this modern text also contains an extensive bibliography for the interested reader.

Introduction; Biological characteristics of actin; Functional properties of actin; Actin structure; The actin sequence; Molecular genetic manipulation of actin; Actin structure; Covalent derivation sites; Post-translational sites; Post-translational modificaiton sites; Proteolytic cleavage sites; Ligand-binding sites; Cation-binding sites; Nucleotide-binding sites; Self-association sites; Actin-binding-protein sites; Drug and toxin binding; Acknowledgements; Bibliography; Protein Sequence Alignments