Epigenetics

About this book

An understanding of epigenetics is central to research in transcriptional regulation, development, and disease. The second edition of the best-selling Epigenetics textbook builds on the strong foundation of the first edition, expanding from 24 to 36 expertly written chapters. Revised chapters from the first edition cover the basic molecular mechanisms underpinning epigenetic regulation, discussing many cellular processes that rely on this kind of regulation, and survey the studies carried out in the whole spectrum of model organisms in which it has been most studied.

New to Epigenetics is the inclusion of the expanding structural data on the machinery that modifies histones and DNA, giving weight and understanding to the molecular workings of chromatin and epigenetics. Also new is the inclusion of studies showing how chromatin remodeling machinery, and the higher order 3-D organization of the nucleus, are contributing to epigenetic regulation. A chapter is dedicated to the mounting evidence in mouse models of transgenerational epigenetic inheritance. Findings from studies of development, reprogramming, and disease highlight not only the importance of epigenetics but also the potential for epigenetic therapy, as illustrated in chapters covering the immune and neuronal systems, and cancer.

Epigenetics is a major resource for those working in the field, as well as a suitable text for advanced undergraduate and graduate courses on gene regulation.

Contents

1. A Brief History of Epigenetics

Gary Felsenfeld

2. Outlook: Looking into Epigenetics

i) The Discovery of Histone Demethylases

Y.G. Shi and Y. Tsukada

ii) Cellular Reprogramming

K. Takahashi

iii) IncRNAs: Linking RNA to Chromatin

J.L. Rinn

iv) Enhancer RNAs: A Class of Long Noncoding RNAs Synthesized at Enhancers

Tae-Kyung Kim, Martin Hemberg, and Jesse M. Gray

v) Novel Modifications of Cytosine in Genomic DNA

S. Kriaucionis and M. Tahiliani

vi) Plant Mobile Small RNAs

P. Dunoyer, C.W. Melnyk, A. Molnar, and R.K. Slotkin

vii) CpG island Chromatin is Shaped by Recruitment of ZF-CxxC Proteins

N. Blackledge, J. Thomson, and P. Skene

viii) A Bromodomain and Extraterminal Domain Inhibitor (BETi) for Cancer Therapy

J. Qi

ix) BET Inhibitors II

U. Schaefer

x) Histone H3 Mutations in Pediatric Brain Tumors

X. Liu, T. McEachron, J. Schwartzentruber, and G. Wu

xi) Chromosome Folding: Driver or Passenger of Epigenetic State

T. Sexton and E. Yaffe

3. Overview and Concepts

C. David Allis, Thomas Jenuwein, Danny Reinberg

4. Writers and Readers of Histone Acetylation: Structure, Mechanism and Inhibition

Ronen Marmorstein and Ming-Ming Zhou

5. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

Edward Seto and Minoru Yoshida

6. Structural and Functional Coordination of DNA and Histone Methylation

Ziaodong Cheng

7. A Structural Perspective on Readout of Epigenetic H & DM Marks

D. Patel

8. Epigenetics in Saccharomyces cerevisiae

Michael Grunstein and Susan M. Gasser

9. Epigenetics in Saccharomyces pombe

R. Allshire and K. Ekwall

10. Neurospora crassa, a Model System for Epigenetics Research

Rodolfo Aramayo and Eric U. Selker

11. Epigenetics of Ciliates

Douglas L. Chalker, Eric Meyer, and Kazufumi Mochizuki

12. Position Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila

Sarah C.R. Elgin and Gunter Reuter

13. Epigenetic Regulation in Plants

C. Pikaard and O. Mittelsten Scheid

14. The Use of Mouse Models to Study Epigenetics

Marnie Blewitt and Emma Whitelaw

15. DNA Methylation in Mammals

En Li and Yi Zhang

16. RNAi and Primal RNAs

R. Martienssen and D. Moazed

17. Transcriptional Silencing by Polycomb Group Proteins

U. Grossniklaus and R. Paro

18. Transcriptional Regulation by Trithorax Group Proteins

R. Kingston and J. Tamkun

19. Long-range Chromatin Interactions

J. Dekker and T. Misteli

20. Histone Variants and Epigenetic Inheritance

S. Henikoff and M. Smith

21. Nucleosome Remodeling and Epigenetics

P.B. Becker and J.L. Workman

22. Maintenance of Epigenetic Information

G. Almouzni and H. Cedar

23. Regulation of the X Chromosomes in C. elegans

Susan Strome, William G. Kelly, Sevinc Ercan, and Jason D. Lieb

24. Dosage Compensation in Drosophila

M. Kuroda and J. Lucchesi

25. Dosage Compensation in Mammals

N. Brockdorff and B. Turner

26. Genomic Imprinting in Mammals

Denise P. Barlow and Marisa S. Bartolomei

27. Germ Line and Pluripotent Stem Cells

A Surani and W. Reik

28. Induced Pluripotency and Epigenetic Reprogramming

K. Hochedlinger and R. Jaenisch

29. Epigenetic Control of Immunity

M. Busslinger and A. Tarakhovsky

30. Metabolic Signalling to Chromatin

S. Berger and P. Sassone-Corsi

31. Epigenetic Regulation in Plant Responses to the Environment

D. Baulcombe and C. Dean

32. Epigenetic Regulation in Neuronal Development

S. Lomvardas and T. Maniatis

33. Epigenetics and Human Disease

A. Beaudet and H. Zoghbi

34. Epigenetic Determinants of Cancer

P. Jones and S. Baylin

35. Epigenetics and Cancer II

J. Audia and R. Campbell

36. Perspectives on Epigenetics

V. Pirrotta

Customer Reviews

Biography

Edited by C. David Allis, The Rockefeller University; Marie-Laure Caparros, London; Thomas Jenuwein, Max-Planck Institute of Immunobiology and Epigenetics; Danny Reinberg, Howard Hughes Medical Institute, New York University School of Medicine-Smilow Research Center; Associate Editor Monika Lachner, Max-Planck Institute of Immunobiology and Epigenetic