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Viruses are everywhere, infecting all sorts of living organisms, from the tiniest bacteria to the largest mammals. Many are harmful parasites, but viruses also play a major role as drivers of our evolution as a species and are essential regulators of the composition and complexity of ecosystems on a global scale. This concise book draws on complex systems theory to provide a fresh look at viral origins, populations, and evolution, and the coevolutionary dynamics of viruses and their hosts.
New viruses continue to emerge that threaten people, crops, and farm animals. Viruses constantly evade our immune systems, and antiviral therapies and vaccination campaigns can be powerless against them. These unique characteristics of virus biology are a consequence of their tremendous evolutionary potential, which enables viruses to quickly adapt to any environmental challenge. Ricard Solé and Santiago Elena present a unified framework for understanding viruses as complex adaptive systems. They show how the application of complex systems theory to viral dynamics has provided new insights into the development of AIDS in patients infected with HIV-1, the emergence of new antigenic variants of the influenza A virus, and other cutting-edge advances.
Essential reading for biologists, physicists, and mathematicians interested in complexity, Viruses as Complex Adaptive Systems also extends the analogy of viruses to the evolution of other replicators such as computer viruses, cancer, and languages.
Ricard Solé is research professor and head of the Complex Systems Lab at Pompeu Fabra University in Barcelona. His books include Phase Transitions and Self-Organization in Complex Ecosystems (both Princeton). Santiago F. Elena is professor and head of the Evolutionary Systems Virology Lab at the Spanish National Research Council (CSIC) in Valencia.
"This book demonstrates how viruses, besides being fascinating organisms, can provide experimental tests and case studies for many of the evolutionary processes that are important to biologists."
– Lin Chao, University of California, San Diego
"This stimulating and timely book addresses questions central to virus population dynamics from the conceptual framework of complex systems theory. Clearly structured and easy to read, it fills a gap and will appeal to scientists in a diversity of fields, from virology to mathematical biology."
– Fernando García-Arenal, Universidad Politécnica de Madrid
"Viruses as Complex Adaptive Systems covers the evolution, diversity, and behavior of viruses from a mathematical perspective, providing a broad range of vignettes on the subject that are clear and engagingly written. The book also serves as a useful introduction to some aspects of theoretical biology."
– Oliver Pybus, University of Oxford
"Solé and Elena bring together in one place a variety of different concepts and approaches that are normally treated separately, offering detailed discussions of the rapid contemporary variation of some viruses along with the medium and long-term evolution of others. I know of no other book like this one."
– Colin R. Parrish, Cornell University
