Adults of the Orsodacnidae and Chrysomelidae, including Bruchinae, from South Carolina are keyed and described. These leaf beetles and seed weevils total 498 species in 139 genera that have been reported from or are likely to occur in the state. Included are diagnostic keys and diagrams to aid in identification, a photograph of one species from each genus, data on range both in South Carolina and in North America, months of collection of adults in South Carolina, and host plants. Fifty-one new state records are noted.