Mass Spectrometry Basics

About this book

Mass Spectrometry Basics provides authoritative yet plain-spoken explanations of the basic concepts of this powerful analytical method without elaborate mathematical derivations. The authors describe processes, applications, and the underlying science in a concise manner supported by figures and graphics to further comprehension. The text provides practical approaches to interpreting mass spectral data and step-by-step guides for identifying chemically relevant compounds. Additionally, the authors have included an extensive reference section and a quick guide to each chapter that offers immediate access to key information.This unique reference makes some of the esoteric aspects of this important area of analysis more readily comprehensible to those who deal with analytical instruments but who have not been trained in mass spectrometry. It also serves as a refresher for practicing mass spectroscopists by clarifying principles to afford a better appreciation and application of this technology.

Contents

Chemical Ionisation. Laser Desorption Ionisation. Electron Ionisation. Fast Atom Bombardment (FAB) and Liquid Phase Secondary Ion Mass Spectrometry (LSIMS) Ionisation. Field Ionisation and Field Desorption. Coronas, Plasmas and Arcs. Thermal Ionisation. Electrospray Ionisation. Atmospheric Pressure Ionisation. Z-Spray Combined Inlet/Ion Source. Thermospray and Plasmaspray Interface. Particle-Beam Interface. Dynamic FAB LSIMS Interface. Plasma Torches. Sample Inlets for Plasma Torches Parts A, B, C: Gases, Liquid Inlet, Solid Inlets. Lasers and Other Light Sources. Nebulizers. Hybrid Orthogonal-TOF Instruments. Hybrid Magnetic Sector-TOF. Hybrid Hexapole-TOF. Hybrid Quadrupole-TOF. Ion Optics of Magnetic/Electric Sector MS. Quadrupole Ion Optics. TOF Ion Optics. Orthogonal TOF Ion Optics. Point Ion Collectors. Array Collectors. Comparison of Multipoint Ion Collectors. Time-to-Digital Converters. Origin and Uses of Metastable Ions. Linked Scanning and Metastable Ions in Quadrupole MS. Linked Scanning and Metastable Ions in Magnetic Sector MS. Gas and Liquid Chromatography. GC/MS. LC/MS. HR Accurate Mass-Elemental Composition. Choice of Mass Spectrometer. Analysis of Peptides and Proteins by MS. EPA Protocols. Computers and Transputers in MS, Parts A, B, C. An Introduction to Biotechnology. Isotopes and MS. Use of Isotope Ratios. Variations in Isotope Ratios. Transmission of Ions through Inhomogeneous RF Fields. Appendices.

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